The transcriptional repressor REST is a major negative regulator of endocrine differentiation during pancreas organogenesis
Meritxell Rovira, Goutham Atla, Miguel Angel Maestro, Vane Grau, Javier García-Hurtado, María Maqueda, José Luis Mosquera, Yasuhiro Yamada, Julie A. Kerr-Conte, François N. Pattou, Jorge P. Ferrer
The paper shows REST inhibits pancreatic endocrine differentiation in mice, zebrafish, and human organoids, identifying it as a key negative regulator.
bioRxiv · Mar 17, 2021Developmental Biology