Meritxell Rovira

This study identifies HNF1B and NPHP3 mutations as causes of a new pancreatic disease, ciliogenic pancreatopathy, characterized by acinar atrophy and adipose replacement, and links ciliary dysfunction to pancreatic dysfunction in humans and mice.

This study identifies spatially distinct cell populations in human pancreatic ducts and shows that ASCP better preserves native cell identities compared to PDAC.

This study identifies ΔNP63 as a marker for exocrine-committed multipotent progenitors in the murine pancreas, showing its role in exocrine development and differentiation.

This study identifies a DNA methylation signature preserved during pancreatic carcinogenesis that distinguishes PDAC origins and influences tumor behavior.

This study identifies noncoding regulatory regions and their mutations in insulinomas, linking them to altered β-cell function and tumor development.

This study identifies 15 novel ductal cell populations in the mouse pancreas using scRNA-seq and investigates their roles in regeneration and exocrine pathogenesis.

The paper evaluates the Hnf1b-CreERT2 reporter system in adult pancreatic duct and δ cells, finding high recombination efficiency in duct cells but low in β cells and partial activation in δ cells.

The paper shows REST inhibits pancreatic endocrine differentiation in mice, zebrafish, and human organoids, identifying it as a key negative regulator.