Caspase-Driven Microvascular Inflammation and Hypoperfusion in Intravascular Hemolysis: Roles of Leukocyte and Endothelial Activation
Pâmela L. Brito, Lucas Fernando Sérgio Gushiken, Érica M.F. Gotardo, Vanessa Figueiredo, Flávia C. Leonardo, Fernando Ferreira Costa, Nicola Conran
This study identifies caspase-1 as a driver of vascular inflammation and hypoperfusion in intravascular hemolysis, showing its role in endothelial-leukocyte recruitment and microvascular dysfunction.
bioRxiv · Mar 10, 2025 · PreprintPhysiology