Synthesizing Combination Therapies for Evolutionary Dynamics of Disease for Nonlinear Pharmacodynamics
Vanessa Jonsson, Nikolai Matni, Richard M. Murray
The paper extends a previous algorithm for designing combination therapies by modeling nonlinear pharmacodynamics using piecewise linear approximations and optimal controller synthesis for positive systems.
bioRxiv · Sep 21, 2014 · PreprintEvolutionary Biology