Synthesis of mRNA lipid nanoparticles for engineering GD2 CAR T and CAR NK cells against neuroblastoma
Chih-Chun Chang, Lei Shi, Soon Ho Choi, Andrea Pennati, Vasiliki Valkanioti, Christian M. Capitini, Sandro Mecozzi, Jacques Galipeau
This study develops mRNA lipid nanoparticles to deliver GD2 CAR genes to T and NK cells, showing effective neuroblastoma targeting and killing in vitro.
bioRxiv · Dec 17, 2025 · PreprintCancer Biology