Pathogenic BRCA1 DBD variants exhibit altered DNA binding affinities and susceptibility to menadione
Emma Cismas, Esme Lowry, Vereena Salib, Kaitlin Lowran, Colin G. Wu
This study examines how specific BRCA1 DNA binding domain variants affect DNA binding affinities and DNA damage response in human cells.
bioRxiv · Jul 10, 2025 · PreprintBiochemistry