Kaitlin Lowran

Loss of TAFAZZIN leads to perturbation of amino acid metabolism and reduction of collagen synthesis

TAFAZZIN-knockout C2C12 myoblasts show elevated proline catabolism into the TCA cycle alongside reduced collagen content, proline hydroxylation, crosslinking enzyme LOX, and proline incorporation into ECM proteins.

Insulin preservatives trigger neutrophil extracellular trap formation through SYNE1-mediated nuclear disassembly

This study shows that insulin preservatives induce NETosis through SYNE1 disruption, reducing inflammation in a porcine model when preservatives are removed.

Domain-specific DNA binding activities of BRCA1 reveal substrate preferences for homologous recombination and telomere regulation

This study identifies DNA binding preferences of BRCA1 domains, showing DBD1 binds dsDNA and DBD2/BRCT bind ssDNA and G4, linking them to HR and telomere regulation.

8-Oxoguanine Disrupts G-Quadruplex DNA Stability and Modulates FANCJ AKKQ Binding

This paper investigates how 8-oxoguanine modifications affect G-quadruplex DNA stability and FANCJ AKKQ binding through experimental assays.

Pathogenic BRCA1 DBD variants exhibit altered DNA binding affinities and susceptibility to menadione

This study examines how specific BRCA1 DNA binding domain variants affect DNA binding affinities and DNA damage response in human cells.