Neurodevelopmental deficits and cell-type-specific transcriptomic perturbations in a mouse model of HNRNPU haploinsufficiency
Sarah A. Dugger, Ryan S. Dhindsa, Gabriela Louise de Almeida Sampaio, Andrew K. Ressler, Elizabeth E. Rafikian, Sabrina Petri, Verity A. Letts, Jia Jie Teoh, Junqiang Ye, Sophie Colombo, Mu Yang, Michael J. Boland, Wayne N. Frankel, David B. Goldstein
This study examines HNRNPU haploinsufficiency in mice, identifying neuroanatomical and transcriptomic changes, and highlights cell-type-specific gene expression dysregulation in excitatory neurons.
bioRxiv · May 1, 2020 · PreprintNeuroscience