Mu Yang

This study shows that immunoproteasome deficiency in mice worsens tau and amyloid pathology by impairing microglial clearance.

This study shows that 5-HT4 receptor agonists reduce tau pathology and improve cognitive function in PS19 mice with tauopathy.

This paper uses multi-omic integration to identify molecular subtypes of aging in brain tissue, finding subtypes associated with cognitive decline.

This study examines HNRNPU haploinsufficiency in mice, identifying neuroanatomical and transcriptomic changes, and highlights cell-type-specific gene expression dysregulation in excitatory neurons.

This study shows that Arfgef1 haploinsufficiency in mice reduces dendritic surface GABAAR and alters endosome composition, leading to increased seizure susceptibility.