Spatial context of cellular heterogeneity in triple-negative breast cancer reveals actionable subtypes
Zahra Mesrizadeh, Kavitha Mukund, Lu Yang, Raju K. Pillai, David Eugene Frankhouser, Daniel Schmolze, Susan L. Neuhausen, Jovanny Zabaleta, Luis Del Valle, Jerneja Tomšič, Yuan Chun Ding, A. Matas Ochoa, Lucio Miele, Victoria Seewaldt, Shankar Subramaniam
The paper identifies three TNBC subtypes based on spatial transcriptomics and cellular mapping, revealing distinct tumor microenvironment architectures and potential therapeutic targets.
bioRxiv · Oct 13, 2026 · PreprintCancer Biology