Raju K. Pillai

Spatial Landscape of Pregnancy-Associated Triple Negative Breast Cancer and Mammary Gland Involution

This study compares transcriptional differences between pre- and post-involution PA-TNBC tissues using spatial transcriptomics, identifying distinct inflammatory and chromatin remodeling patterns in post-involution tumors.

Spatial context of cellular heterogeneity in triple-negative breast cancer reveals actionable subtypes

The paper identifies three TNBC subtypes based on spatial transcriptomics and cellular mapping, revealing distinct tumor microenvironment architectures and potential therapeutic targets.

Hi-C for genome-wide detection of enhancer-hijacking rearrangements in routine lymphoid cancer biopsies

This study uses FFPE-compatible Hi-C to detect enhancer-hijacking rearrangements in lymphoid cancers, identifying clinically relevant drivers missed by standard methods.

Spatially distinct cellular and molecular landscapes define prognosis in triple negative breast cancer

This study uses spatial transcriptomics to identify molecular and cellular differences between good and poor prognosis triple-negative breast cancer subtypes, revealing distinct gene signatures that could inform therapy.

Dysfunctional β-cell longevity in diabetes relies on high energy conservation and positive epistasis

The paper identifies PFKFB3-expressing dysfunctional β-cells in T2D, showing their survival via positive epistasis and reduced clearance, and demonstrates PFKFB3 inhibition restores glucose tolerance in mice.