Impaired mitochondrial stress signaling mediates bone loss in male mice in the absence of BNIP3.
Li Tian, Victoria Van Berlo, Vivin Karthik, Joshua P. Passarelli, Victoria DeMambro, Patience Mudjgiwa, Calvin Vary, Anyonya R. Guntur
This study shows that BNIP3 and mitophagy are essential for mitochondrial stress relief during osteoblast differentiation, which is necessary for maintaining bone mass in male mice.
bioRxiv · Apr 8, 2026 · PreprintCell Biology