Victoria DeMambro

Exosome Trafficking Is a Key Regulator of Adipocyte Thermogenesis

This study identifies exosome trafficking as a key regulator of beige adipocyte thermogenesis, showing that exosome release enhances thermogenic output and energy expenditure.

Impaired mitochondrial stress signaling mediates bone loss in male mice in the absence of BNIP3.

This study shows that BNIP3 and mitophagy are essential for mitochondrial stress relief during osteoblast differentiation, which is necessary for maintaining bone mass in male mice.

In C57Bl6 Mice, Obesity and Subsequent Weight Loss Negatively Affected the Skeleton and Shifted the Cortical Bone Metabolome

This study shows that obesity and calorie restriction both harm bone health in mice, with calorie restriction causing more severe bone loss and metabolic changes in a sex-dependent manner.

Isoform-Specific Control of Adipose Thermogenesis by the miR-27 Family Reveals Antagonism within a Polycistronic miRNA Cluster

This study shows that miR-27a and miR-27b regulate adipose thermogenesis and metabolism, with their combined loss enhancing thermogenic activity and metabolic health.

Re-Evaluating One-step Generation of Mice Carrying Conditional Alleles by CRISPR-Cas9-Mediated Genome Editing Technology

The paper re-evaluates the efficiency of a CRISPR-Cas9 method for generating conditional knockout alleles in mice, finding very low success rates and high rates of undesired alleles.