Signaling induced biophysical disruption of repressed chromatin domains drives immune cell fate
Alexia Martínez de Paz, Christopher R. Chin, Mythili Ketavarapu, Yuchen Sun, Matthew R. Marunde, Jeremy T.-H. Chang, Laiba F Khan, John Cohen, Rui Yang, Michael J. Bale, Andrew W. Daman, Vigneshwari E. Kumar, Chenyang Jiang, Dughan J. Ahimovic, Mark Owyong, , Steven Zvi Josefowicz
The paper identifies H3 serine 28 phosphorylation as a mechanism driving chromatin derepression and immune cell fate transitions by disrupting repressive chromatin domains.
bioRxiv · Dec 11, 2025 · PreprintImmunology