Christopher R. Chin

Signaling induced biophysical disruption of repressed chromatin domains drives immune cell fate

The paper identifies H3 serine 28 phosphorylation as a mechanism driving chromatin derepression and immune cell fate transitions by disrupting repressive chromatin domains.

Deep dynamical models of single-cell multiomic velocities predict loss-of-function and rescue perturbations in B cells

ChromaFold predicts the 3D contact map from single-cell chromatin accessibility

ChromaFold predicts 3D chromatin contact maps from scATAC-seq data, outperforming bulk-based methods and enabling cell-type-specific interaction analysis.

Multi-omics Analysis of Dsup Expressing Human Cells Reveals Open Chromatin Architectural Dynamics Underyling Radioprotection

This study investigates how Dsup expression in human cells affects chromatin structure and radioprotection through multi-omic analyses.