Small-molecule-based regulation of gene expression in human astrocytes upon both positive and negative actuations of G-quadruplex control systems
Vijay Kumar M J, Jérémie Mitteaux, Zi Wang, Ellery Wheeler, Nitin Tandon, Sung Yun Jung, Robert H. E. Hudson, David Monchaud, Andrey S. Tsvetkov
This study compares the effects of G-quadruplex stabilization and destabilization on gene expression in human astrocytes using PDS and PhpC, revealing distinct transcriptomic and proteomic responses.
Journal of Biological Chemistry · Nov 28, 2024Peer-reviewedGenetics