Sung Yun Jung

This study shows that pathogenic ATAD3A mutations disrupt the RagC/D-TFEB axis, leading to lysosomal dysfunction and neurodevelopmental defects.

The paper identifies a female-biased IL-17/STAT3 signaling program in microglia associated with dementia in Alzheimer's disease using single-cell transcriptomics.

The paper identifies the CHIP-LMO7-BAG5 complex as a regulator of tau clearance and develops therapeutic candidates targeting this complex for Alzheimer's disease.

This study identifies FBXL21 as a circadian E3 ligase that regulates proteostasis and stress response by targeting DNAJB6 and its client proteins, with implications for myopathies.

This study identifies S-acylation of CRY1 as a critical post-translational modification regulated by DHHC3, essential for its nuclear localization and repressor function in the circadian clock.

This study identifies a liver-to-atria inflammatory axis driven by osteopontin in MASH, leading to atrial remodeling and arrhythmia, with potential therapeutic targets.

The paper evaluates NF1-derived single amino acid variants as HLA class I neoantigens using computational prediction and experimental validation, finding discrepancies between predictions and observed sequences.

This paper shows HDAC11 de-fatty acylates SF3B2 at K10, altering its pre-mRNA binding and promoting AR-v7 splicing in HCC cells, but not in prostate cancer cells.

This study identifies KDM4A as a critical factor for cilia assembly and maintenance by interacting with Rootletin and maintaining basal body architecture.

This paper identifies AADAT as a metabolic immune checkpoint in TNBC that promotes immune evasion by regulating malate and CoQ10, and shows that malate supplementation can reverse immunotherapy resistance.

The paper identifies CD44 as an OPN receptor in astrocytes that regulates lipid metabolism and glial communication in Alzheimer's disease.

COOKIE-Pro quantifies covalent inhibitor binding kinetics across the proteome, revealing off-targets and kinetic parameters for BTK inhibitors.

This study identifies PPARα as a regulator of liver proteostasis, showing it suppresses protein synthesis and secretion while enhancing proteasome activity and degradation.

This study identifies PI3K-mTOR pathway inhibition as a strategy to overcome acquired resistance to KRASG12C inhibitors in NSCLC by targeting 4E-BP1.

This study compares the effects of G-quadruplex stabilization and destabilization on gene expression in human astrocytes using PDS and PhpC, revealing distinct transcriptomic and proteomic responses.

This study shows PCIF1 is cytoplasmic, localizes to stress granules, and binds mRNA coding regions during oxidative stress, suggesting a role in RNA surveillance independent of its methyltransferase activity.

This study identifies CAMKV kinase signaling as a critical driver of neuroblastoma growth and shows it as a potential therapeutic target and prognostic marker.

This study identifies CK2-dependent phosphorylation of Daam2 as a regulatory mechanism controlling oligodendrocyte development and myelin repair through Wnt signaling.

This study identifies Slc4a4's role in maintaining blood-brain barrier integrity through the NO-CCL2-CCR2 pathway in astrocytes, showing its importance in both healthy and stroke conditions.

This study analyzes genomic and proteomic differences between recurrent and non-recurrent discrete subaortic stenosis patients to identify predictive markers for reoccurrence.

This study shows that 3' sequence identity is not required for the established function of miR-146a in myeloid cells in vivo.