Author

Robert H. E. Hudson

Western UniversityORCID 0000-0002-6530-6479Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

David MonchaudiD· 2 shared Andrey S. TsvetkoviD· 1 shared Angélique PipieriD· 1 shared Ellery Wheeler· 1 shared Garance PsalmoniD· 1 shared Jérémie MitteauxiD· 1 shared Manon Barbotte· 1 shared Nitin TandoniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

David MonchaudORCID

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2 papers

Recent·Most cited

The DNA damaging properties of the experimental G-quadruplex (G4) drug QN-302 are potentiated by the DNA repair inhibitor Olaparib and mitigated by the molecular helicase PhpC

Garance Psalmon, Angélique Pipier, Manon Barbotte, Robert H. E. Hudson, Stephen Neidle, David Monchaud

This study shows QN-302 damages DNA at G4 sites in cancer cells and its anticancer effect is enhanced by Olaparib, a DNA repair inhibitor.

bioRxiv · Feb 9, 2026 · PreprintCancer Biology

Small-molecule-based regulation of gene expression in human astrocytes upon both positive and negative actuations of G-quadruplex control systems

Vijay Kumar M J, Jérémie Mitteaux, Zi Wang, Ellery Wheeler, Nitin Tandon, Sung Yun Jung, Robert H. E. Hudson, David Monchaud, Andrey S. Tsvetkov

This study compares the effects of G-quadruplex stabilization and destabilization on gene expression in human astrocytes using PDS and PhpC, revealing distinct transcriptomic and proteomic responses.

Journal of Biological Chemistry · Nov 28, 2024Peer-reviewedGenetics