Fibroblast-derived thrombospondin-1 shapes macrophage polarization in advanced human co-culture models
Kristina Draganić, Sergey Isaev, Isabella Pototschnig, Daniel Valcanover, Janette Pfneissl, Mira Stadler, Marcos Hocevar, Vincent Lotz, Gabriel Wasinger, Céline Pisibon, Luisa Grader, Alina Sou Yan Ho, Małgorzata S. Małys, Piyal Saha, Renate Kain, , Gerda Egger
This study uses advanced human co-culture models to show that fibroblast-derived thrombospondin-1 drives macrophage metabolic remodeling and polarization in tumor environments.
bioRxiv · May 29, 2026 · PreprintCancer Biology