The "DDVF" motif used by viral and bacterial proteins to hijack RSK kinases evolved as a mimic of a short linear motif (SLiM) found in proteins related to the RAS-ERK MAP kinase pathway.
Martin Veinstein, Vincent Stroobant, Fanny Wavreil, Thomas Michiels, Frédéric Sorgeloos
The paper identifies human proteins that interact with RSK kinases via DDVF-like SLiMs, showing pathogens mimic these motifs to alter RAS-ERK MAPK pathway regulation.
PLoS Pathogens · Mar 28, 2025Peer-reviewedMicrobiology