A systematic analysis of IBD GWAS loci identifies most probable causal genes impacting intestinal epithelial functions
Isabelle Hébert-Milette, Virginie Mercier, Jean Paquette, Gabrielle Boucher, Chloé Lévesque, Philippe Goyette, John David Rioux
This paper identifies causal genes in IBD GWAS loci by combining genetic, genomic, and functional data, finding that IRF6 enhances and IRF8 suppresses antiviral responses in intestinal epithelial cells.
medRxiv · Aug 2, 2026 · PreprintGenetic & Genomic Medicine