Author
Montreal Heart InstituteORCID 0000-0003-2132-8817Unclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
4 papers
Recent·Most cited
Isabelle Hébert-Milette, Virginie Mercier, Jean Paquette…·John David Rioux
This paper identifies causal genes in IBD GWAS loci by combining genetic, genomic, and functional data, finding that IRF6 enhances and IRF8 suppresses antiviral responses in intestinal epithelial cells.
Isabelle Hébert-Milette, Chloé Lévesque, Jean Paquette…·John David Rioux
This study shows that C1ORF106 and its IBD variant regulate intestinal barrier permeability by controlling tight junctions, cell polarity, and F-actin dynamics through a ROCK-dependent mechanism.
Aleksejs Sazonovs, Christine R. Stevens, Guhan Ram Venkataraman…·Rasha Shawky
The paper identifies ten new genes with coding variants linked to Crohn's disease risk using sequencing data from over 30,000 patients and 80,000 controls.
Jessy Carol Ntunzwenimana, Gabrielle Boucher, Jean Paquette…·Brian White‐Guay
The paper functionally screens IBD genes in intestinal epithelial cells to identify their roles in epithelial structure and function, revealing DUSP16's role in mucosal defense.