Gabrielle Boucher

This paper identifies causal genes in IBD GWAS loci by combining genetic, genomic, and functional data, finding that IRF6 enhances and IRF8 suppresses antiviral responses in intestinal epithelial cells.

This study improves the reproducibility of antigen-specific T cell detection using standardized AIM assay workflows and automated analysis tools.

The paper identifies enriched coding variants in a French-Canadian founder population and explores their association with inflammatory bowel diseases.

This study shows that C1ORF106 and its IBD variant regulate intestinal barrier permeability by controlling tight junctions, cell polarity, and F-actin dynamics through a ROCK-dependent mechanism.

The paper identifies four IBD-associated genes that regulate calprotectin expression in myeloid cells and shows their role in prostaglandin signaling pathways linked to IBD susceptibility.

The paper functionally screens IBD genes in intestinal epithelial cells to identify their roles in epithelial structure and function, revealing DUSP16's role in mucosal defense.

This study identifies shared and ethnicity-specific HLA associations with ulcerative colitis through trans-ethnic analysis of diverse populations.

This study fine-maps 94 inflammatory bowel disease loci to identify 45 causal variants with high confidence, providing insights into their functional impacts on disease mechanisms.