Identification of key Y4R residues enables the discovery of selective non-peptide small-molecule agonists
Tim Pelczyk, Corinna Schüß, Mateusz Sklodowski, Fabian Ließmann, David Jordan, Vivian Ehrlich, Paul Eisenhuth, Jan Stichel, Albert Owusu Gattor, Max Keller, Jens Meiler, Annette Gabriele Beck‐Sickinger
This study identifies key Y4R residues and discovers selective non-peptide small-molecule agonists through molecular docking, residue replacement, and ultra-large library screening.
bioRxiv · May 1, 2026 · PreprintBiochemistry