Image-based spatial transcriptomics identifies molecular niche dysregulation associated with distal lung remodeling in pulmonary fibrosis
Annika Vannan, Ruqian Lyu, Arianna L. Williams-Katek, Nicholas M. Negretti, Evan D. Mee, Joseph Hirsh, Samuel Hirsh, Niran Hadad, David S. Nichols, Carla L. Calvi, Chase J. Taylor, VV Polosukhin, Ana Paula Moreira Serezani, A. Scott McCall, Jason J. Gokey, , Nicholas E. Banovich
Xenium profiling of 343 genes in 1,126,820 nuclei from 19 human lungs maps fibrosis niches and orders alveolar remodeling from alveolar-capillary disruption to SPP1+ macrophage accumulation.
Nature Genetics · Feb 3, 2025Peer-reviewedGenomics✦ In-depth digest