Niran Hadad

This study uses spatial transcriptomics to analyze gene expression in heart transplant recipients during rejection, identifying distinct transcriptomic profiles associated with different rejection types and outcomes.

The paper identifies inflammatory fibroblasts that promote lung repair by enhancing epithelial proliferation through BMP signaling, validated across multiple models and human disease.

This paper creates a spatial transcriptomic atlas of acute neonatal lung injury across development and disease severity using 1.2 million cells from 17 human infant lungs.

This study identifies gene-diet interactions that influence cognitive resilience to Alzheimer's disease in mice, finding a diet-dependent genetic locus associated with resilience.

Xenium profiling of 343 genes in 1,126,820 nuclei from 19 human lungs maps fibrosis niches and orders alveolar remodeling from alveolar-capillary disruption to SPP1+ macrophage accumulation.

This study investigates the association between mosaic loss of chromosome Y (mLOY) and pulmonary fibrosis, finding mLOY correlates with age and telomere length but not disease severity, and suggests a potential link between telomere shortening and mLOY.

The paper analyzes genetic diversity's effect on brain composition in an Alzheimer's disease mouse model using an enhanced QUINT workflow.

The paper identifies a genetic locus and protein associated with resilience to cognitive decline in AD-BXD mice and links it to human AD traits.

RNA Strain-Match matches RNA sequencing alignment data to genotype without variant call files, correcting 13% of sample mismatches in mouse models.

The paper investigates how chromosomal content and gonadal sex influence gene expression and DNA modification patterns in mouse hippocampi, revealing sex chromosome-specific regulatory effects.

The paper identifies a cell-type specific signature of cognitive resilience to Alzheimer's disease in human and mouse models, highlighting excitatory intratelencephalic cortical neurons and several resilience genes.

This study identifies genetic variants and pathways associated with cognitive resilience to Alzheimer's disease, finding a novel locus linked to bile acid metabolism and methylation changes.

The paper shows that early life DNA methylation patterns predict age-related transcriptome changes in mice, supporting the developmental origins of disease hypothesis.

This study shows that caloric restriction reduces age-related DNA methylation changes in the hippocampus of mice, including both CG and non-CG sites, and introduces CR-specific methylation patterns linked to gene expression changes.

This study identifies sexually divergent DNA methylation changes in mouse and human hippocampus with aging, revealing sex as a key factor in epigenomic aging.