Conserved tau microtubule-binding repeat histidines confer pH-dependent tau-microtubule association
R. A. Charafeddine, W. A. Cortopassi, P. Lak, M. P. Jacobson, D. L. Barber, T. Wittmann
This study identifies conserved histidine residues in tau that act as pH sensors modulating tau-microtubule binding through electrostatic and hydrophobic interactions.
bioRxiv · Dec 4, 2018Cell Biology