R. A. Charafeddine

Doublecortin reinforces microtubules to promote growth cone advance in soft environments

This study shows DCX stabilizes microtubules in growth cones, enabling neuron morphogenesis in soft environments by resisting actomyosin contractile forces.

Growth cone advance requires EB1 as revealed by genomic replacement with a light-sensitive variant

This study replaces endogenous EB1 with a light-sensitive variant in human neurons to show EB1's role in growth cone dynamics and neurite guidance through optogenetic inactivation.

Conserved tau microtubule-binding repeat histidines confer pH-dependent tau-microtubule association

This study identifies conserved histidine residues in tau that act as pH sensors modulating tau-microtubule binding through electrostatic and hydrophobic interactions.