D. L. Barber

The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication

This study shows that pre-existing lung inflammation reduces SARS-CoV-2 replication by activating innate immune pathways, highlighting the role of the inflammatory microenvironment in controlling viral infection.

Arp2/3 Complex Activity Enables Nuclear YAP for Naive Pluripotency of Human Embryonic Stem Cells

This study identifies Arp2/3 complex activity as essential for nuclear YAP translocation and naive pluripotency in human embryonic stem cells through actin remodeling and Hippo signaling regulation.

Blood and site of disease inflammatory profiles differ in HIV-1-infected pericardial tuberculosis patients

This study compares inflammatory profiles in blood and pericardial fluid of HIV-1-infected individuals with latent TB, PTB, and PCTB, finding site-specific elevation of analytes and HLA-DR as a better TB diagnostic marker.

IL-10 suppresses T cell expansion while promoting tissue-resident memory cell formation during SARS-CoV-2 infection in rhesus macaques

This study examines the roles of IFNγ and IL-10 in SARS-CoV-2 infection of rhesus macaques, finding IL-10 suppresses T cell expansion but promotes tissue-resident memory cell formation.

Spatial mapping of human lung tissue reveals granuloma diversity and histopathological superstructure in tuberculosis

This study maps spatial immune cell composition in human TB lung tissue, revealing diverse non-necrotizing aggregates surrounding necrotizing granulomas.

Rapid GPR183-mediated recruitment of eosinophils to the lung after Mycobacterium tuberculosis infection

This study shows that eosinophils migrate to the lungs early after Mycobacterium tuberculosis infection in mice and macaques, mediated by GPR183 and Ch25h, independent of CCR3.

Mild SARS-CoV-2 infection in rhesus macaques is associated with viral control prior to antigen-specific T cell responses in tissues

This study shows that SARS-CoV-2 replication declines in the lungs before T cell responses, while innate immunity restricts viral replication in nasal and oral mucosa in rhesus macaques.

CD4 T cells are rapidly depleted from tuberculosis granulomas following acute SIV co-infection

This study shows that acute SIV co-infection rapidly depletes CD4 T cells from tuberculosis granulomas before systemic CD4 T cell loss or disease reactivation.

Arp2/3 complex activity is necessary for mouse ESC differentiation, times formative pluripotency, and enables lineage specification

This study shows that Arp2/3 complex activity is necessary for morphology changes during mESC differentiation, regulates differentiation markers, and enables lineage specification.

Eosinophils are an integral component of the pulmonary granulocyte response in Tuberculosis and promote host resistance in mice

This study shows eosinophils are recruited to tuberculosis-infected lung tissue in mice and contribute to host resistance against Mtb infection.

Functional inactivation of pulmonary MAIT cells following 5-OP-RU treatment of non-human primates

This study shows that 5-OP-RU treatment of M. tuberculosis-infected rhesus macaques leads to MAIT cell dysfunction rather than expansion, with upregulated PD-1 and loss of cytokine production.

PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques

This study shows that PD-1 blockade worsens Mycobacterium tuberculosis infection in rhesus macaques by increasing bacterial loads and altering immune responses.

pHLARE: A Genetically Encoded Ratiometric Lysosome pH Biosensor

The paper introduces pHLARE, a genetically encoded ratiometric lysosome pH biosensor, and demonstrates its use in showing decreased lysosome pH in cancer cell lines.

An acidic residue buried in the dimer interface of isocitrate dehydrogenase 1 (IDH1) helps regulate catalysis and pH sensitivity

This paper identifies an acidic residue in IDH1 that regulates catalysis and pH sensitivity through conformational changes.

Conserved tau microtubule-binding repeat histidines confer pH-dependent tau-microtubule association

This study identifies conserved histidine residues in tau that act as pH sensors modulating tau-microtubule binding through electrostatic and hydrophobic interactions.