Author

W. C. Liles

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

A. M. Manicone· 1 shared C. F. Hung· 1 shared E. A. Hemann· 1 shared K. B. Hisert· 1 shared M. De· 1 shared M. E. Long· 1 shared S. Gharib· 1 shared S. Holton· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperImmunology

A. M. Manicone

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2 papers

Recent·Most cited

MEK1/2 inhibition decreases pro-inflammatory responses in macrophages from people with cystic fibrosis and mitigates severity of illness in experimental murine methicillin-resistant Staphylococcus aureus infection

M. De, K. B. Hisert, W. C. Liles, A. M. Manicone, E. A. Hemann, M. E. Long

This study shows MEK1/2 inhibitors reduce inflammation in CF macrophages and improve outcomes in MRSA-infected mice without affecting pathogen clearance.

bioRxiv · Jan 22, 2023 · PreprintImmunology

PERICYTE-LIKE CELLS UNDERGO TRANSCRIPTIONAL REPROGRAMMING AND DISTINCT FUNCTIONAL ADAPTATIONS IN ACUTE LUNG INJURY

C. F. Hung, S. Holton, Y.-H. Chow, W. C. Liles, S. Gharib, W. A. Altemeier

This study examines transcriptional and functional changes in pericyte-like cells in response to BALF from injured and uninjured lungs in a mouse model of acute lung injury, finding sustained responses to injured BALF.

bioRxiv · Nov 15, 2019Cell Biology