Medication-related osteonecrosis of the jaws after tooth extraction in senescent female mice treated with zoledronic acid: microtomographic, histological and immunohistochemical characterization
C. C. Biguetti, A. H. De Oliva, K. Healy, R. H. Mahmoud, I. D. C. Custodio, D. H. Constantino, E. Ervolino, M. A. H. Duarte, W. D. Fakhouri, M. A. Matsumoto
This study characterizes MRONJ development in senescent female mice treated with zoledronic acid using microCT, histology, and immunohistochemistry, showing delayed bone healing and increased inflammation.
bioRxiv · Mar 11, 2019Immunology