Author

K. Healy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 4 Cell Biology· 2 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 7 Approach:experimental assay· 6 Research Focus:cell type annotation· 4 Research Focus:drug response / drug discovery· 4 Approach:deep learning· 2 Assay:electrophysiology· 2 Assay:organoid / primary culture· 2 Assay:spatial transcriptomics· 2

Frequent Co-Authors

V. Charwat· 4 shared A. Tveito· 2 shared B. Charrez· 2 shared B. Siemons· 2 shared E. Miller· 2 shared H. Finsberg· 2 shared I. Goswami· 2 shared K. H. Jaeger· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersBioengineering

V. Charwat

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

The microenvironment dictates glycocalyx construction and immune surveillance

K. Tharp, S. Park, G. A. Timblin, A. Richards, J. Berg, N. Twells, N. M. Riley, E. Peltan, D. J. Shon, E. Stevenson, C. K. Tsui, F. Palomba, A. E. Lefebvre, R. Soens, N. Ayad, , V. Weaver

This study shows that the physical properties of the microenvironment influence glycocalyx composition and immune surveillance in vitro using physiologically relevant models.

bioRxiv · Jun 23, 2023 · PreprintCell Biology

Multiplexed microfluidic platform for stem-cell derived pancreatic islet β cells

I. Goswami, E. de Klerk, P. Carnese, M. Hebrok, K. Healy

This paper introduces a scalable microfluidic platform for culturing stem-cell derived β cells, demonstrating viability and functionality over a week and showing responses to drug exposure and metabolic challenges.

bioRxiv · May 23, 2022Bioengineering

In Vitro Safety "Clinical Trial" of the Cardiac Liability of Hydroxychloroquine and Azithromycin as COVID19 Polytherapy

B. Charrez, V. Charwat, B. Siemons, H. Finsberg, A. Edwards, E. Miller, K. Healy

This paper uses a cardiac microphysiological system to assess the cardiotoxicity of hydroxychloroquine and azithromycin polytherapy, finding increased QT interval and reduced arrhythmias compared to monotherapy.

bioRxiv · Dec 21, 2020 · PreprintBioengineering

Identifying drug response by combining measurements of the membrane potential, the cytosolic calcium concentration, and the extracellular potential in microphysiological systems

K. H. Jaeger, S. Wall, V. Charwat, K. Healy, A. Tveito

The paper combines membrane potential, cytosolic calcium, and extracellular potential measurements to accurately estimate sodium channel current density and drug effects in hiPSC-CMs.

bioRxiv · May 29, 2020Bioengineering

Integrated hiPSC-based liver and heart microphysiological systems predict unsafe drug-drug interaction

F. T. Lee-Montiel, A. Laemmle, L. Dumont, C. S. Lee, N. Huebsch, V. Charwat, H. Okochi, M. J. Hancock, B. Siemons, S. C. Boggess, I. Goswami, E. Miller, H. Willenbring, K. Healy

The paper integrates hiPSC-based liver and heart microphysiological systems to predict drug-drug interactions, showing ketoconazole inhibits cisapride metabolism, causing arrhythmia in cardiac MPSs.

bioRxiv · May 24, 2020 · PreprintBioengineering

Disease-relevant single cell photonic signatures identify S100β stem cells and their myogenic progeny in vascular lesions

C. Molony, D. King, M. di Luca, M. Kitching, A. Olayinka, R. Hakimjavadi, L. A. Julius, E. Fitzpatrick, Y. Gusti, D. Burtenshaw, K. Healy, E. K. Finlay, D. Kernan, A. Llobera, W. Liu, , P. A. Cahill

bioRxiv · May 13, 2020Cell Biology

Improved computational identification of drug response using optical measurements of human stem cell derived cardiomyocytes in microphysiological systems

K. H. Jaeger, V. Charwat, B. Charrez, H. Finsberg, M. M. Maleckar, S. Wall, K. Healy, A. Tveito

The paper improves computational methods to identify drug responses in mature human stem cell-derived cardiomyocytes using optical measurements and mathematical modeling.

bioRxiv · Oct 1, 2019Biophysics

Medication-related osteonecrosis of the jaws after tooth extraction in senescent female mice treated with zoledronic acid: microtomographic, histological and immunohistochemical characterization

C. C. Biguetti, A. H. De Oliva, K. Healy, R. H. Mahmoud, I. D. C. Custodio, D. H. Constantino, E. Ervolino, M. A. H. Duarte, W. D. Fakhouri, M. A. Matsumoto

This study characterizes MRONJ development in senescent female mice treated with zoledronic acid using microCT, histology, and immunohistochemistry, showing delayed bone healing and increased inflammation.

bioRxiv · Mar 11, 2019Immunology