Author

W. Heiger-Bernays

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 4

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1

Frequent Co-Authors

G. Nielsen· 2 shared H. Puckett· 2 shared J. J. Schlezinger· 2 shared J. Oliver· 2 shared J. Schlezinger· 2 shared T. F. Webster· 2 shared T. Webster· 2 shared C. Boston· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersPharmacology & Toxicology

G. Nielsen

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4 papers

Recent·Most cited

Predicting the Effects of Per- and Polyfluoroalkyl Substance Mixtures on Peroxisome Proliferator-Activated Receptor Alpha Activity in Vitro

G. Nielsen, W. Heiger-Bernays, J. Schlezinger, T. Webster

This study evaluates modeling approaches to predict the effects of PFAS mixtures on hPPAR activity in vitro, finding that GCA provides the most accurate predictions for diverse agonist and antagonist combinations.

bioRxiv · Sep 30, 2021Pharmacology & Toxicology

Perfluorooctanoic Acid Induces Liver and Serum Dyslipidemia in Humanized PPARα Mice Fed an American Diet

J. J. Schlezinger, T. Hyotylainen, T. Sinioja, C. Boston, H. Puckett, J. Oliver, W. Heiger-Bernays, T. F. Webster

This study shows PFOA affects lipid levels in hPPAR mice on an American diet, with context-dependent effects on liver and serum triglycerides.

bioRxiv · Apr 3, 2021Pharmacology & Toxicology

Predicting the activation of the androgen receptor by mixtures of ligands using Generalized Concentration Addition

J. J. Schlezinger, W. Heiger-Bernays, T. F. Webster

This study develops Generalized Concentration Addition (GCA) to predict the activity of androgen receptor ligand mixtures, showing it outperforms traditional methods.

bioRxiv · May 2, 2020Pharmacology & Toxicology

Perfluorooctanoic acid activates multiple nuclear receptor pathways and skews expression of genes regulating cholesterol homeostasis in liver of humanized PPARα mice fed an American diet

J. Schlezinger, H. Puckett, J. Oliver, G. Nielsen, W. Heiger-Bernays, T. Webster

This study shows PFOA exposure increases liver mass and alters cholesterol-related gene expression in hPPAR mice fed an American diet.

bioRxiv · Jan 30, 2020Pharmacology & Toxicology