Multiscale mechanistic modelling of the host defense in invasiveaspergillosis reveals leukocyte activation and iron acquisition as driversof infection outcome
Henrique AL Ribeiro, Luis Sordo Vieira, Yogesh M. Scindia, Bandita Adhikari, Matthew Wheeler, Adam Knapp, W. J. Schroeder, Borna Mehrad, Reinhard Laubenbacher
This study develops a multiscale computational model of invasive aspergillosis to identify key factors determining infection outcome, finding that fungal growth, iron acquisition, and leukocyte activation are critical.
bioRxiv · Jun 8, 2021 · PreprintSystems Biology