Author

W. L. Wang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 3 Organism:human· 3 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Approach:deep learning· 1

Frequent Co-Authors

Y. Mao· 3 shared S. Zhang· 2 shared Y. Dong· 2 shared Y. Lu· 2 shared Y. Zhu· 2 shared Z. Wu· 2 shared D. Finley· 1 shared D. Yu· 1 shared

Activity by Year

2017-2020 · peak 1/yr

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10 top collaborators · 32 mutual co-author links

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3 shared papersBiochemistry

Y. Mao

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3 papers

Recent·Most cited

Hidden dynamics of ubiquitin-mediated autoregulation of human 26S proteasome during substrate degradation

Z. Wu, E. Chen, S. Zou, Y. Hou, S. Zhang, W. L. Wang, Y. Dong, Y. Mao

The paper uses cryo-EM and deep learning to analyze human 26S proteasome conformers, revealing dynamics of ubiquitin-mediated autoregulation during substrate degradation.

bioRxiv · Dec 22, 2020 · PreprintBiochemistry

Visualizing ATP-dependent substrate-processing dynamics of the human 26S proteasome at near-atomic resolution

Y. Dong, S. Zhang, Z. Wu, X. Li, W. L. Wang, Y. Zhu, S. Stoilova-McPhie, Y. Lu, D. Finley, Y. Mao

The paper presents cryo-EM structures of the human 26S proteasome in seven conformational states during polyubiquitylated protein degradation, revealing dynamic substrate-proteasome interactions and ATP hydrolysis mechanisms.

bioRxiv · Sep 16, 2018Biochemistry

Nucleotide-Driven Triple-State Remodeling Of The AAA-ATPase Channel In The Activated Human 26S Proteasome

Y. Zhu, W. L. Wang, D. Yu, Q. Ouyang, Y. Lu, Y. Mao

This study identifies three states of the ATP-gammaS-bound human proteasome, showing nucleotide-driven remodeling of the AAA-ATPase channel controls CP gate opening.

bioRxiv · May 1, 2017Biochemistry