Author

W. P. Galej

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:cryo-EM· 2 Research Focus:protein structure prediction· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

A. Fraudeau· 1 shared D. Peter· 1 shared I. Brandina· 1 shared J. Zhao· 1 shared K. Nagai· 1 shared M. E. Wilkinson· 1 shared M. M. Pfleiderer· 1 shared M. Razew· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperBiochemistry

A. Fraudeau

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3 papers

Recent·Most cited

Structure of the minor spliceosomal U11 snRNP

J. Zhao, D. Peter, I. Brandina, X. Liu, W. P. Galej

The paper presents a cryo-EM structure of the U11 snRNP complex, revealing its unique architecture and interactions critical for U12-dependent intron recognition.

Molecular Cell · Feb 1, 2025Peer-reviewedBiochemistry

Structural basis of the Integrator complex assembly and association with transcription factors

M. Razew, A. Fraudeau, M. M. Pfleiderer, W. P. Galej

This paper reports cryo-EM structures of Integrator sub-complexes and identifies ZNF655 as a TF interacting with Integrator, suggesting a role in transcription regulation.

bioRxiv · Jan 30, 2024Biochemistry

Structural basis for conformational equilibrium of the catalytic spliceosome

M. E. Wilkinson, S. M. Fica, W. P. Galej, K. Nagai

The paper presents an electron cryo-microscopy structure of the yeast C complex, revealing a novel intermediate that explains the conformational equilibrium of the spliceosome.

bioRxiv · Sep 22, 2020Biophysics