M. E. Wilkinson

Control of 3' splice site selection by the yeast splicing factor Fyv6

This study investigates how the yeast splicing factor Fyv6 influences 3' splice site selection through transcriptomic, structural, and genetic analyses.

Similar mechanisms of retron-mediated anti-phage defense for different families of tailed phages

This study identifies Retron-Eco11 as a bacterial defense system that uses helicase proteins to trigger effector toxicity against phage infection.

Data-driven regularisation lowers the size barrier of cryo-EM structure determination

This paper introduces a deep-learning-based regularisation method for cryo-EM that improves reconstruction quality, enabling structure determination of smaller macromolecules with low signal-to-noise ratios.

Structural basis for conformational equilibrium of the catalytic spliceosome

The paper presents an electron cryo-microscopy structure of the yeast C complex, revealing a novel intermediate that explains the conformational equilibrium of the spliceosome.