Early Detection of Apathetic Phenotypes in Huntington’s Disease Knock-in Mice Using Open Source Tools
S. Minnig, R. M. Bragg, H. S. Tiwana, W. T. Solem, W. S. Hovander, E.-M. S. Vik, M. Hamilton, S. R. W. Legg, D. D. Shuttleworth, S. R. Coffey, J. P. Cantle, J. B. Carroll
The paper develops an open-source operant system to detect apathetic phenotypes in Huntington’s disease mice, finding reduced progressive ratio task performance in HttQ111/+ mice at 9-11 months.
bioRxiv · Oct 25, 2017Animal Behavior & Cognition