Author

J. P. Cantle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Animal Behavior & Cognition· 1 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Assay:behavioral assay· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

J. B. Carroll· 3 shared R. M. Bragg· 2 shared S. R. Coffey· 2 shared S. R. W. Legg· 2 shared A. Hutchinson· 1 shared A. J. R. Heck· 1 shared A. Lemak· 1 shared A. Seitova· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersCell Biology

J. B. Carroll

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Author profile →

3 papers

Recent·Most cited

Huntingtin loss in hepatocytes is associated with altered metabolism, adhesion, and liver zonation

R. M. Bragg, S. R. Coffey, J. P. Cantle, S. Hu, S. Singh, S. R. W. Legg, C. A. McHugh, A. Toor, S. O. Zeitlin, S. Kwak, D. Howland, T. F. Vogt, S. P. Monga, J. B. Carroll

This study shows that reducing huntingtin in liver cells leads to metabolic changes, altered cell adhesion, and disrupted liver zonation patterns in mice.

bioRxiv · Jun 24, 2023 · PreprintCell Biology

HAP40 orchestrates huntingtin structure for differential interaction with polyglutamine expanded exon 1

R. J. Harding, J. C. Deme, J. F. Hevler, S. Tamara, A. Lemak, J. P. Cantle, M. M. Szewczyk, X. Zuo, P. Loppnau, A. Seitova, A. Hutchinson, L. Fan, M. Schapira, J. B. Carroll, A. J. R. Heck, , C. H. Arrowsmith

This study reveals how HAP40 orchestrates HTT structure, affecting its interaction with polyglutamine-expanded exon 1, providing insights into Huntington's disease mechanisms.

bioRxiv · Apr 2, 2021Biochemistry

Early Detection of Apathetic Phenotypes in Huntington’s Disease Knock-in Mice Using Open Source Tools

S. Minnig, R. M. Bragg, H. S. Tiwana, W. T. Solem, W. S. Hovander, E.-M. S. Vik, M. Hamilton, S. R. W. Legg, D. D. Shuttleworth, S. R. Coffey, J. P. Cantle, J. B. Carroll

The paper develops an open-source operant system to detect apathetic phenotypes in Huntington’s disease mice, finding reduced progressive ratio task performance in HttQ111/+ mice at 9-11 months.

bioRxiv · Oct 25, 2017Animal Behavior & Cognition