Structure and Function of an in vivo Assembled Type III-A CRISPR-Cas Complex Reveal Critical Roles of Dynamics in Activity Control
S. Sridhara, J. Rai, C. Whyms, W. Woodside, M. P. Terns, H. Li
The paper structures and functionally characterizes an in vivo assembled Type III-A CRISPR-Cas complex, revealing how RNA binding controls its enzymatic activity through protein dynamics.
bioRxiv · Jan 27, 2021Biophysics