CRISPR/Cas9-mediated integration of large transgene into pig potential safe harbor
G. Li, X. Zhang, H. Wang, J. Mo, C. Zhong, J. Shi, R. Zhou, Z. Li, H. Yang, W. Z. Fang, L. D. Wu
This study develops an efficient CRISPR/Cas9 method for integrating a large transgene cassette into the CEP112 locus in pigs, achieving successful expression of microbial enzymes in salivary glands.
bioRxiv · Aug 1, 2019 · PreprintBioengineering