SARS-CoV-2 infection alkalinizes the ERGIC and lysosomes through the viroporin activity of the viral envelope protein
W.-A. Want, A. Carreras Sureda, N. Demaurex
This study shows SARS-CoV-2 envelope protein alkalinizes ERGIC and lysosomes by acting as a proton channel, affecting viral replication and pathogenicity.
bioRxiv · Oct 4, 2022Physiology