W.-C. Ho

Trade-offs, trade-ups, and high mutational parallelism underlie microbial adaptation to extreme feast/famine

This study experimentally evolved E. coli populations under feast/famine cycles, finding high mutational parallelism and trade-offs between growth and survival traits.

Consideration of a liquid mutation accumulation experiment to measure mutation rates by successive serial dilution.

The paper proposes a liquid-phase mutation-accumulation experiment to measure mutation rates and spectra, demonstrating it can replicate results from plate-based experiments and detect a modified mutation spectrum.

Evolutionary dynamics of asexual hypermutators adapting to a novel environment

This study evolves E. coli populations with different mutation rates in a complex medium for 900 days and finds that higher mutation rates do not significantly increase fitness improvement despite faster genome evolution.

Evolutionary Response to Resource Deprivation: Parallelism and Nonmonotonicity

This study shows that intermediate starvation periods in E. coli lead to distinct phenotypes not predicted by extremes, suggesting non-monotonic evolutionary forces.

Testing the neutral hypothesis of phenotypic evolution

The paper tests the neutral hypothesis of phenotypic evolution by analyzing morphological and gene expression traits in yeast, finding adaptive evolution in morphology but not in gene expression.