W.-F. Xue

Structural reconstruction of individual filaments in Abeta42 fibril populations assembled in vitro reveal rare species that resemble ex vivo amyloid polymorphs from human brains

The paper uses atomic force microscopy and cryo-electron microscopy to analyze Aβ42 fibril structures in vitro, identifying rare polymorphs similar to those found in human brain amyloid.

Trace_y: Software algorithms for structural analysis of individual helical filaments by three-dimensional contact point reconstruction atomic force microscopy

Trace_y reconstructs 3D contact point clouds from AFM height images to analyze individual helical filament structures.

Structural identification of individual helical amyloid filaments by integration of cryo-electron microscopy-derived maps in comparative morphometric atomic force microscopy image analysis

This paper develops a method to identify individual amyloid fibril structures using AFM with cryo-EM maps, showing dGAE fibrils are structurally distinct from heparin-induced tau fibrils and related to Alzheimer's PHFs.

Amyloid particles facilitate surface-catalyzed cross-seeding by acting as promiscuous nanoparticles

This study shows amyloid seeds can catalyze cross-seeding without propagating their specific conformation, using Aβ42 and Sup35NM proteins.

The Division of Amyloid Fibrils - Systematic comparison of fibril fragmentation stability by linking theory with experiments

This study compares the fragmentation stability of different amyloid fibrils using experiments and a mathematical model, revealing differences in dynamic stability between disease-related and model amyloid.

Three-dimensional reconstruction of individual helical nano-filament structures from atomic force microscopy topographs

This paper demonstrates a method to reconstruct 3D structures of individual helical nano-filaments from AFM topographs by using contact-point based deconvolution to overcome tip-sample convolution effects.

Quantification of amyloid fibril polymorphism by nano-morphometry reveals the individuality of filament assembly

This study quantifies amyloid fibril polymorphism using nano-morphometry and AFM, revealing structural heterogeneity and its implications for amyloid assembly and disease.

A Cell Culture Platform For Cryptosporidium That Enables Long-Term Cultivation And New Tools For The Systematic Investigation Of Its Biology