J. Cinatl

Resistance patterns in drug-adapted cancer cell lines reflect complex evolution in clinical tumors

This study identifies drug-resistant sublines of TNBC cell lines and finds that resistance mechanisms are unique and unpredictable, suggesting new potential drug targets.

Repurposing of the antibiotic nitroxoline for the treatment of mpox

This study shows nitroxoline, an antibiotic, inhibits mpox virus replication and remains effective against tecovirimat-resistant strains, suggesting it as a repurposing candidate for mpox treatment.

Omicron-induced interferon signalling prevents influenza A virus infection

This study shows Omicron variants induce interferon responses in human cells, protecting against influenza A virus super-infection, while Delta does not.

Synergism of interferon-beta with antiviral drugs against SARS-CoV-2 variants

This study evaluates the antiviral efficacy of interferon-beta combined with antiviral drugs against SARS-CoV-2 variants, finding synergistic effects with certain drugs against specific variants.

Identification of novel antiviral drug candidates using an optimized SARS-CoV-2 phenotypic screening platform

This study develops a phenotypic screening platform using caspase 3/7 activity to identify antiviral compounds against SARS-CoV-2, including novel candidates and combinations.

Development and optimisation of a high-throughput screening assay for in vitro anti-SARS-CoV-2 activity: evaluation of 5676 phase 1 passed structures

The paper develops a high-throughput screening assay to evaluate 5676 phase 1 compounds for in vitro anti-SARS-CoV-2 activity, identifying eight candidates but finding only remdesivir suitable for further clinical development.

USP22 controls type III interferon signaling and SARS-CoV-2 infection through activation of STING

This study identifies USP22 as a regulator of STING and type III IFN signaling, showing its role in SARS-CoV-2 infection and antiviral defense in human intestinal epithelial cells.

SARS-CoV-2 Omicron variant virus isolates are highly sensitive to interferon treatment

This study shows that SARS-CoV-2 Omicron variants are more sensitive to interferon treatment than Delta variants, suggesting interferons could be effective therapies for Omicron infections.

Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells

This study identifies intrinsic and acquired resistance mechanisms to CNDAC and related nucleoside analogues in AML cells, showing distinct roles of SAMHD1 and DCK.

Multifaceted roles of SAMHD1 in cancer

This study analyzes SAMHD1's role in cancer using TCGA and TARGET databases, finding no consistent tumour suppressor effect and suggesting context-dependent pro-or anti-tumourigenic effects.

Characterization of protease activity of Nsp3 from SARS-CoV-2 and its in vitro inhibition by nanobodies

This study characterizes Nsp3 protease activity from SARS-CoV-2 and identifies nanobodies that inhibit PLpro with nanomolar affinity.

In Vitro Activity of Itraconazole Against SARS-CoV-2

This paper assesses the in vitro antiviral activity of itraconazole and its metabolite against SARS-CoV-2, finding EC50 values of 2.3 μM and 3.6 μM, respectively, and reports no clinical efficacy in hospitalized patients.

Evaluation of stability and inactivation methods of SARS-CoV-2 in context of laboratory settings

This study evaluates inactivation methods for SARS-CoV-2 in laboratory settings, finding that some lysis buffers and chemical treatments effectively inactivate the virus, while others do not.

Targeting pentose phosphate pathway for SARS-CoV-2 therapy

This study identifies the pentose phosphate pathway as a target for SARS-CoV-2 therapy and shows that inhibiting it with benfooxythiamine reduces viral replication.

SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytes

This study shows SARS-CoV-2 infects human cardiomyocytes, causing cytotoxicity and apoptosis, and confirms this in cardiac tissue models.

Drug-adapted cancer cell lines reveal drug-induced heterogeneity and enable the identification of biomarker candidates for the acquired resistance setting

The paper investigates drug-induced heterogeneity in cancer cell lines and identifies biomarkers for acquired resistance to YM155.

Testing of the survivin suppressant YM155 in a large panel of drug-resistant neuroblastoma cell lines

This study tests YM155 in 101 neuroblastoma cell lines, revealing ABCB1 and ABCC1 as mediators of resistance and highlighting cross-resistance differences between drug-adapted lines.

SAMHD1 is a key regulator of the lineage-specific response of acute lymphoblastic leukaemias to nelarabine

This study identifies SAMHD1 as a key regulator of nelarabine response in acute lymphoblastic leukaemias, showing lineage-specific differences in SAMHD1 expression and methylation.

A novel exosome biogenesis mechanism: multivesicular structures budding and rupturing at the plasma membrane

The paper identifies a novel exosome release mechanism where multivesicular structures protrude from the plasma membrane and rupture to release exosomes, distinct from the conventional multivesicular endosome fusion process.

The thrombopoietin receptor agonist eltrombopag inhibits human cytomegalovirus replication via iron chelation

This paper shows eltrombopag inhibits HCMV replication via iron chelation, effective against drug-resistant strains and synergistic with ganciclovir.

Doxorubicin-loaded human serum albumin nanoparticles overcome transporter-mediated drug resistance

This study shows that doxorubicin-loaded human serum albumin nanoparticles enhance anti-cancer activity in drug-resistant neuroblastoma cells by bypassing ABCB1-mediated efflux.

Elevated expression of LGR5 and WNT signalling factors in neuroblastoma cells with acquired drug resistance

This study shows that LGR5 and WNT signaling factors are elevated in neuroblastoma cell lines with acquired drug resistance, suggesting a role for the WNT pathway in resistance mechanisms.

TP53 mutations and drug sensitivity in acute myeloid leukaemia cells with acquired MDM2 inhibitor resistance

This study establishes MDM2 inhibitor-resistant AML sub-lines and finds that resistance arises from pre-existing TP53 mutations or de novo mutations, with variable drug sensitivity despite loss of p53 function.

Incorporation of doxorubicin in different polymer nanoparticles and their anti-cancer activity

This study compares the anti-cancer activity of doxorubicin-loaded nanoparticles made from different polymers and preparation methods, finding significant differences in efficacy based on size, drug load, and release kinetics.

Drug repurposing: omeprazole increases the efficacy of acyclovir against herpes simplex virus type 1 and 2

This paper shows that omeprazole enhances acyclovir's effectiveness against herpes simplex virus 1 and 2 in cell cultures without harming cell viability.

The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1

This study investigates how cancer drugs interact with SAMHD1's catalytic and allosteric sites, finding that drug efficacy is affected by SAMHD1 activity and that only cladribine-TP induces the active tetramer.

Primary cilia mediate diverse kinase inhibitor resistance mechanisms in cancer

The paper investigates how primary cilia contribute to kinase inhibitor resistance in cancer by altering cilia structure and function, leading to enhanced hedgehog pathway activation and drug resistance.

A Cell Culture Platform For Cryptosporidium That Enables Long-Term Cultivation And New Tools For The Systematic Investigation Of Its Biology