Multi-ancestry genome-wide and transcriptome-wide association analyses identify new risk loci and genes for inflammatory bowel disease
Xingyi Guo, Linshuoshuo Lyu, Chao Li, Ghadeer K. Dawwas, You Chen, Ran Tao, Qi Liu, Wan Wen, Xiao-Ou Shu, Kay Washington, David A Schwartz, Wei Zheng, Zhijun Yin, Ken S. Lau
This study identifies 60 new susceptibility loci and 441 candidate risk genes for inflammatory bowel disease through multi-ancestry GWAS and TWAS, with implications for precision medicine.
medRxiv · Sep 23, 2025 · PreprintGenetic & Genomic Medicine