Wei Zheng

Single-cell transcriptome-wide association analysis reveals epithelial cell-specific genetic susceptibility to colorectal cancer

The paper performs single-cell transcriptome-wide association analysis to identify cell-type-specific genetic susceptibility genes for colorectal cancer, finding 546 gene-cell-type associations and 347 candidate susceptibility genes.

PRANA: A Deep Learning Method for Adapting Polygenic Risk Scores to Diverse Ethnic Groups

PRANA adapts polygenic risk scores to non-European populations, improving predictive accuracy by 5%-20% in South Asian, East Asian, and Ashkenazi Jewish populations.

A Multi-Dataset Transcriptomic Analysis Unravels Core Mechanisms Involving Vitamin D Metabolism and Inflammatory Pathways for Frailty Diagnosis.

This study identifies molecular signatures for frailty using transcriptomic data from two datasets, highlighting vitamin D metabolism and inflammatory pathways as key features.

ProteinConformers: large-scale and energetically profiled descriptions of protein conformational landscapes

ProteinConformers provides a large-scale dataset of protein conformations with energy profiles and similarity annotations, offering a benchmarking framework and analysis platform.

Multi-ancestry genome-wide and transcriptome-wide association analyses identify new risk loci and genes for inflammatory bowel disease

This study identifies 60 new susceptibility loci and 441 candidate risk genes for inflammatory bowel disease through multi-ancestry GWAS and TWAS, with implications for precision medicine.

Effective structure-aware protein alignment via residue-level contrastive learning

CLAlign improves protein alignment by using contrastive learning to generate structure-aware embeddings, outperforming both unsupervised and sequence-based methods.

Rapid and prolonged response of oligodendrocyte lineage cells in standard acute cuprizone demyelination model revealed by in situ hybridization

The paper uses in situ hybridization to track oligodendrocyte lineage cell dynamics during demyelination and remyelination in a cuprizone model, revealing early mature oligodendrocyte death and prolonged myelin-forming cell activity.

Identification of Novel Common Breast Cancer Risk Variants in Latinas at the 6q25 Locus

The paper identifies three novel common breast cancer risk variants at the 6q25 locus in Latinas and replicates their association in diverse populations.