You Chen

The paper performs single-cell transcriptome-wide association analysis to identify cell-type-specific genetic susceptibility genes for colorectal cancer, finding 546 gene-cell-type associations and 347 candidate susceptibility genes.

Adding OneK1K immune cell-type expression edges to an updated PrimeKG modestly improved drug-indication link prediction, AUPRC 0.816 to 0.826 overall and 0.847 to 0.864 for 40 autoimmune diseases.

scCotag improves single-cell multi-omics integration by using co-optimal transport and regularized barycentric mapping, outperforming existing methods in alignment and embedding accuracy.

This study identifies 60 new susceptibility loci and 441 candidate risk genes for inflammatory bowel disease through multi-ancestry GWAS and TWAS, with implications for precision medicine.