When GWAS meets the Connectivity Map: drug repositioning for seven psychiatric disorders
Hon‐Cheong So, Carlos Kwan‐Long Chau, Wan-To Chiu, Kin-Sang Ho, Cho-Pong Lo, Stephanie Ho-Yue Yim, Pak Chung Sham
This study repositions drugs for seven psychiatric disorders by comparing GWAS-imputed transcriptomes with drug expression profiles from the Connectivity Map, identifying novel candidates supported by preclinical or clinical evidence.
bioRxiv · Dec 23, 2016 · PreprintGenomics