Carlos Kwan‐Long Chau

This study uses Mendelian randomization to find that triglycerides causally link to depression symptoms and self-harm, while HDL cholesterol shows weaker associations.

This paper introduces a framework integrating GWAS-derived transcriptomes and clinical data to subtype complex diseases, showing improved clustering performance and biological relevance in schizophrenia and cardiovascular risk stratification.

This study uses Mendelian randomization to investigate statin repositioning opportunities and side-effects across 55 traits, finding associations between LDL-C reduction and various outcomes.

This study uses GWAS gene-set analyses to reposition drugs for depression and anxiety, finding enrichment of psychiatric medications and new candidates like fendiline.

This study identifies shared genetic factors between depression subtypes and cardiometabolic risks, suggesting subtype-specific associations and potential drug repositioning opportunities.

This study repositions drugs for seven psychiatric disorders by comparing GWAS-imputed transcriptomes with drug expression profiles from the Connectivity Map, identifying novel candidates supported by preclinical or clinical evidence.